In recent years scientific and technological advances have been made in development of controlled oral drug delivery system by overcoming physiological adversities, such as short residence time and unpredictable gastric emptying time (GET). Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. The gastroretention could help to provide greater availability of new products and improve therapeutic activity and substantial benefits to patients. Floating Drug delivery system are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level a swell as improving bioavailability.
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